新型分子探针及功能材料研发及应用，开展18F-FDG PET/CT影像组学在肿瘤诊治中相关应用研究，推动正电子核素药物标记反应发生器国产化商品化，解决设备进口依赖问题。

现在承担和参与的课题：

［1］上海市抗癌协会项目，68Ga-FAPI与18F-FDG PET/CT在胃肠道粘液腺癌和印戒细胞癌的临床研究， HYXH2021004，项目经费 24.8万，2021.01-2023.12，在研，主持。

［2］上海申康医院发展中心项目，PSMA SPECT/PET/CT显像用于前列腺癌精准诊断的关键技术及推广应用， NO. SHDC22020219,项目经费30万，2020.12- 2022.11，在研，主持。

［3］国家重点研发计划，食品污染物去除技术及污染食品高值化催化利用技术开发，项目编号No.2019YFC1604605，项目经费120万，2020.01-2022.12，在研，主持。

［4］上海市科学技术委员会基金项目，小动物分子影像设备共享管理优化策略，项目编号：19142202100，项目经费10万元，2019.10-2021.09,在研，主持

［5］国家自然科学基金项目，基于PD-1/PD-L1免疫检查点阻断的多功能放射栓塞微球治疗肝癌的研究，项目编号：81971648, 项目经费55万，2020.01-2023.12，在研，主持。

［6］上海市国际科技合作基金项目，多功能抗癌放射性纳米微球光化疗联合栓塞治疗肝癌的实验研究，项目编号：18410711200，项目经费50万，2018.4-2021.3，在研，主持。

［7］国家自然基金面上项目，碘-131标记的多功能诊治一体化微球栓塞治疗肝癌的实验研究，项目编号：81771861，项目经费55万，2018.01-2021.12，在研，主持。

［8］上海交通大学医学院高峰学科—临床医学“研究型医师”人才计划项目，项目编号：20172010，经费100万，2017.07-2020.06，已结题，主持。

［9］上海交通大学“医工(理)交叉研究基金”，甲状腺癌131I治疗个体化管理及辐射剂量预测模型建立，项目编号：YG2016MS55，项目经费 21 万，2017.01-2019.12，已结题，主持。

［10］国家自然基金面上项目，靶向EphB4 的放射性分子探针在体诊治评价，项目编号：81471708，项目经费73万，2015.01-2018.12，已结题，主持。

申请专利情况

［1］脑ASL, SPECT和MRI图像配准融合联合分析的方法及系统，刘冶, 宋少莉，王洋，陈增爱，王利生。ZL2015 1092 8978.9(授权)

［2］恒流培养装置及使用其的γ射线动态监测装置，黄钢, 盛世乐, 宋少莉, ZL 2009 2 0075201.2(授权)

［3］宋少莉,黄钢,甲状腺癌患者口服碘-131后体内放射性碘残留量分析预测系统 [简称:碘-131体内残留量预测系统]V1.0,2016SR203950，原始取得，全部权利, 2016.05.20(授权)

［1］宋少莉（10/13），肺癌代谢重编程机制与关键标志物研究及临床转化应用，中国医疗保健国际促进交流会，二等奖，2020

［2］宋少莉（10/12），基于分子靶点的高效肿瘤检测技术研发和产业化，上海市浦东新区人民政府，一等奖，2018

［3］宋少莉（5/11），正电子发射断层显像技术的临床转化研究与国产化应用，上海市科技进步奖，二等奖, 2011

［4］宋少莉（7/8）, 《正电子发射断层显像的方法学优化及临床应用策略》, 中华医学科技进步奖, 三等奖, 2009

［5］宋少莉，18F-FDG PET/CT早期监测化疗疗效的方法学及机制研究的研究，上海市优秀博士论文，2009

［1］Zhou M#, Song SL#, Zhao J, Tian M, Li C*, Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy, Journal of Materials Chemistry B, 2015, (3):8939-8948. (SCI IF = 4.872)

［2］ Song SL#*，Xiong C, Lu W, Ku G, Huang G, Li C*, Apoptosis imaging probe predicts early chemotherapy response in preclinical models: A comparative study with 18F-FDG PET, Journal of Nuclear Medicine, 2013, 54(1):104-110. (SCI IF =5.563)

［3］ Zhao J#, Song SL#, Zhong M, Li C*, Dual-Modal Tumor Imaging via Long-Circulating Biodegradable Core-Crosslinked Polymeric Micelles, ACS Macro Letters, 2012, 1(1):150-153. (SCI IF = 4.7 )

［4］Song SL#, Xiong CY#, Zhou M, Lu W, Huang Q, Ku G, Zhao J, Flores, Leo G Jr, Ni YC, Li C*, Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin, Journal of Nuclear Medicine, 2011, 52(5):792-799. (SCI IF = 7.022)

［5］Song SL#*, Deng C, Wen LF, Liu JJ, Wang H, Feng D, Wong CY, Huang G*, 18F-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model, Nuclear Medicine and Biology, 2010, 37(3):327-333.（SCI IF = 2.620）

［6］Song SL, Liu JJ, Huang G*, Wang ZH, Song YY, Sun XG, Chen T, Changes in 18F-FDG uptake within minutes after chemotherapy in a rabbit VX2 tumor model. Journal of Nuclear Medicine, 2008, 49(2):303-309. (SCI IF = 6.662)

通讯作者论文

［2］Xinxin Zou, Yanling Yan*, Huajun Chen, Xiao-Lei Shi, Shaoli Song*, Zhi-Gang Chen*，Hierarchical Meso/macro-porous TiO2/Graphitic Carbon Nitride Nanofibers with Enhanced Photocatalytic Activity for Hydrogen Evolution，Meterials and desigh, 2021, 202:109542 (IF=6.457)

［3］Yuyi Qian#, Qiufang Liu#,  Panli Li#, Yaobao Han#, Jianping Zhang, Jiaojiao Xu, Jinwen Sun, Aihua Wu, Shaoli Song*, Wei Lu*, Highly Tumor-Specific and Long-Acting Iodine-131 Microbeads for Enhanced Treatment of Hepatocellular Carcinoma with Low-Dose Radio-Chemoembolization, ACS nano,2021, 15(2):2933-2946. (IF=14.588)

［4］Ziyi Yang, Bingxin Gu, Chunjuan Jiang, Le Zhang, Qiufang Liu, Shaoli Song*, A pH-responsive photoacoustic imaging probe for tumor pH imaging in vivo based on polyaniline–bovine serum albumin, Nanomedicine: Nanotechnology, Biology, and Medicine, 2021:102356. (IF=5.182)

［5］Shuai Liu#, Lingfang Xia#, Ziyi Yang, Huijuan Ge, Chunmei Wang, Herong Pan, Shaoli Song*, Zhengrong Zhou*, The feasibility of 18F-FDG PET/CT for predicting pathologic risk status in early-stage uterine cervical squamous cancer, Cancer imaging, 2020, 20(1):63. (IF=2.193)

［6］Tian Qiwei, Cai Yu, Nan  Li, Liu Qiufang, Gu Bingxin, Chen ZhiGang *, Song Shaoli *. Ellagic  acid–Fe  nanoscale  coordination  polymer  with  higher  longitudinal relaxivity  for  dual-modality  T1-weighted  magnetic  resonance  and photoacoustic  tumor  imaging. Nanomedicine. 2020 Aug;28:102219. doi: 10.1016/j.nano.2020.102219.  

［7］ Wang Beihe#, Liu Chang#, Wei Yu#, Meng Jin, Zhang Yingjian, Gan Hualei, Xu Xiaoping, Wan Fangning, Pan Jian, Ma Xuejun, Hu Silong, Freedland Stephen J, Song Shaoli*, Ye DingWei*, Zhu Yao*. A Prospective Trial of 68Ga-PSMA and 18F-FDG PET/CT in Nonmetastatic Prostate Cancer Patients With an Early PSA Progression During castration(J). Clin Cancer Res. 2020,26(17):4551-4558. （SCI IF=10.3）

［8］Liu Qiufang#, Sun Dazhen#, Li Nan, Kim Jinman, Feng Dagan, Huang Gang, Wang Lisheng*, Song Shaoli*. Predicting EGFR mutation subtypes in lung adenocarcinoma using 18F-FDG PET/CT radiomic features. Transl Lung Cancer Res 2020,9(3):549-562. (SCI IF = 5.13)

［9］Li PL#, Wang XY#, Xu CR#, Liu C, Zheng CJ, Fulham MJ, Feng DG, Wang LS, Song SL*, Huang G*, 18F-FDG PET/CT radiomic predictors of pathologic complete response (pCR) to neoadjucvant chemotherapy in breast cancer patients. Eur J Nucl Med Mol Imaging. 2020 ;47(5):1116-1126. (SCI IF = 7.182)

［10］ Zhang AM, Li PL, Liu QF, Peng SY, Huang G*, Song SL*,Effect of post-sugical RAI therapy on parathyroid function in patients with differentiated thyroid cancer. Endocr Pract. 2020;26(4):416-422. (SCI IF = 4.8)

［11］Zhang AM, Wu T, Bian L, Li PL, Liu QF, Zhang DJ,Jin QM,Zhang J, Huang G*, Song SL*,Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment Induced Tumor Necrosis. Mol Imaing Biol. 2020;22(3):515-525.(SCI IF = 3.341)

［12］Li PL#, Zhang AM#, Liu Y, Xu CY, Tang LL, Yuan H, Liu QF, Wang XY, Feng DG, Wang LS, Huang G*, Song SL*, Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer: Study of External Dose Rate Attenuation Law and Individualized Patient Management. Thyroid. 2019；29(1):93-100. (SCI IF = 7.557)

［13］ Liu QF#, Qian YY#, Li P, Zhang S, Wang Z, Liu J, Sun X, Fulham M, Feng D, Chen Z, Song SL*, Lu W*, Huang G*. The combined therapeutic effects of 131iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer. Acta Pharm Sin B. 2018;8(3):371-380. (SCI IF= 6.)

［14］Liu QF#, Qian YY#, Li PL#, Zhang SH, Liu JJ, Sun XG, Michael Fulham, Feng DG, Huang G*, Lu W*, Song SL*. Combination 131I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization. Theranostics, 2018; 8(3): 785-799. (SCI IF= 8.766.)

［15］ Li PL, Liu QF, Tang DQ, Zhu YY, Xu L, Sun XG, Song SL*, Lesion based diagnostic performance of dual phase 99mTc-MIBI SPECT/CT imaging and ultrasonography in patients with secondary hyperparathyroidism. BMC Med Imaging. 2017;17(1):60. (SCI IF=1.2152.)

［16］Liu QF#，Zhou M#，Li PL，Ku G，Huang G，Li C and Song SL*，64CuS-labeled nanoparticles: a new sentinel lymph node–mapping agent for PET/CT and photoacoustic tomography, contrast media and molecular imaging, 2016;11(6):475-481. (SCI IF = 3.307)

［17］Liu QF，Zheng XJ，Li PL，Xu L，He LW，Zhao M, Zhu YY, Huang G, Zhong CL*, Song SL*，Cerebral Blood Perfusion Changes of Amputees with Myoelectric Hand after Rehabilitation: A SPECT Computer-aided Analysis, BMC neuroscience, 2016;31;17(1):59. (SCI IF = 2.312)

［18］Xu F, Tang L, Yuan H, Liu J, Huang G, Song SL*. Iodine-131 in Helicobacter Pylori Positive Patients: Preliminary Accidental Finding and in Differentiated Thyroid Cancer. Nuclear Medicine Communications. 2016; 37(11):1136-1138. (SCI IF = 1.669)

［19］ Li JD#, Zhang J#, Yang SW, Jiang CH, Zhang DJ, Jin QM, Wang Q, Wang C, Ni YC, Yin ZQ*, Song SL*, Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses, Molecular Pharmaceutics, 2016; 13(1):232-240. (SCI IF = 4.4)

［20］Wu JG, Song SL*, Zhou X, Wang F, Zhu YY, Xie L, Zhang F, Huang G*，Biometabolic Distribution of 99mTc-3PRGD2 and Its Potential Value in Monitoring Chemotherapeutic Effects, Molecular Imaging, 2015;14: 567-576. (SCI IF = 1.96)

［21］Zhang A, Li P, Liu Q, Song SL*, Breast-specific gamma camera imaging with 99mTc-MIBI has better diagnostic performance than magnetic resonance imaging in breast cancer patients: A meta-analysis. Hell J Nucl Med. 2017;20(1):26-35.

［22］ Li P#, Liu Q#, Wang C, Wang T, Liu J, Huang G, Song SL*. Fluorine-18-fluorodeoxyglucose positron emission tomography to evaluate recurrent gastric cancer after surgical resection: a systematic review and meta-analysis. Ann Nucl Med. 2016;30(3):179-187.

［23］ Wang C#, Li P#, Wu S, Lu J, Liu Q, Luo H, Song SL*. The role of fluorine-18 fluorodeoxyglucose PET in prognosis evaluation for stem cell transplantation of lymphoma: a systematic review and meta-analysis. Nucl Med Commun. 2016;37(4):338-347.