开展超声介导下的肿瘤高效治疗和神经调控的前沿基础研究
现在承担和参与的课题：
国家自然科学基金委项目（3项）
1. 国家自然科学基金杰出青年项目，51725202，稀土功能材料，2018/01-2022/12，400万元，在研，主持。
2. 国家自然科学基金面上项目，51872094，铁基多元异质结材料用于肿瘤化学动力学疗法的研究，2019/01-2022/12，60万元，在研，主持。
3. 国家自然科学基金面上项目，51372260，用于高效跨越脑胶质瘤血脑屏障的新型多功能纳米诊疗剂的实验研究，2014/01-2017/12，80万元，已结题，主持。
上海市科委项目（1项）：
1. 上海市基础研究重大研究计划，19JC1412000，化学动力学疗法的材料学基础，2019/10-2022/09，400万元，在研，主持。
人才计划资助项目（1项）：
1. 上海市优秀学术带头人计划，16XD1604000，新型稀土功能材料用于乏氧肿瘤高效诊疗的研究，2016/07-2019/06，40万元，已结题，主持。
1. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.Nature Nanotechnology, 2017, 12 (4), 378-386. （SCI-IF：31.538）
2. Zhongmin Tang, Peiran Zhao, Han Wang, Yanyan Liu*, Wenbo Bu*.Biomedicine meets Fenton chemistry.Chemical Reviews, 2021, 121 (4), 1981-2019. ( Invited Review)（SCI-IF：52.758）
3. Jianan Liu, Wenbo Bu*, Jianlin Shi*.Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.Chemical Reviews, 2017, 117(9): 6160-6224. (Invited Review) （SCI-IF：52.758）
4. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.Chemical Society Reviews, 2017, 46, 7438–7468. (Invited Review) （SCI-IF：42.846）
5. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.Accounts of Chemical Research, 2018, 51(10), 2502-2511. (Invited Review) （SCI-IF：20.835）
6. Jianan Liu, Wenbo Bu*, Jianlin Shi*.Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.Accounts of Chemical Research, 2015, 48 (7): 1797–1805. (Invited Review). （SCI-IF：20.832）
7. Yanyan Liu, Xianfu Meng, Wenbo Bu*.Upconversion-based Photodynamic Cancer Therapy.Coordination Chemistry Reviews, 2019, 379, 82-98. (Invited Review) （SCI-IF：15.367）
8. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.Chem, 2019, 5 (8): 2171-2182. （SCI-IF：19.735）
9. Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu*Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair.Science Advances, 2020, 6 (39), eabc3513.（SCI-IF：13.116）
10. Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi*A highly sensitive and selective nanosensor for near-infrared potassium imagingScience Advances, 2020, 6 (16), eaax9757.（SCI-IF：13.116）
11. Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du*Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.Journal of the American Chemical Society, 2020, 142, 7858-7867.（SCI-IF：14.612）
12. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.Journal of the American Chemical Society, 2019, 141 (2), 849-857. （SCI-IF：14.612）
13. Chen Zhang, Wenbo Bu*, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.Journal of the American Chemical Society, 2016, 138 (26), 8156–8164. （SCI-IF：14.612）
14. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.Journal of the American Chemical Society, 2014, 136 (27), 9701–9709. （SCI-IF：14.612）
15. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.Journal of the American Chemical Society, 2013, 135 (35), 13041-13048 （SCI-IF：14.612）
16. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.Journal of the American Chemical Society, 2013, 135 (17), 6494-6503. （SCI-IF：14.612）
17. Yanli Li, Teng Gong,* Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng,* and Wenbo Bu*ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy.Angewandte Chemie-International Edition, 2021, DOI: 10.1002/anie.202103015.（SCI-IF：12.959）
18. Peiran Zhao, Yaqin Jiang, Zhongmin Tang, Yanli Li, Bingxia Sun, Yelin Wu, Jiyue Wu, Yanyan Liu,* Wenbo Bu*Constructing Electron lever in Perovskite Nanocrystal to Regulate Local Electron Density for Intensive Chemodynamic Therapy.Angewandte Chemie-International Edition, 2021,60,8905–8912.（SCI-IF：12.959）
19. Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu*, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu*Near-infrared Light-triggered Chlorine Radicals (•Cl) Stress for Cancer Therapy Angewandte Chemie-International Edition, 2020, 59, 21032–21040.（SCI-IF：12.959）
20. Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu*.Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy.Angewandte Chemie-International Edition, 2020, 59, 22537–22543.（SCI-IF：12.959）
21. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.Angewandte Chemie-International Edition, 2019, 58 (4), 946-956. （SCI-IF：12.959）
22. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.Angewandte Chemie-International Edition, 2016, 55, 2101-2106. （SCI-IF：12.959）
23. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.Angewandte Chemie-International Edition, 2015, 54, 14026–14030. （SCI-IF：12.959）
24. Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.Angewandte Chemie-International Edition, 2015, 54, 8105–8109. （SCI-IF：12.959）
25. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.Angewandte Chemie-International Edition, 2015, 54: 1770–1774. （SCI-IF：12.959）
26. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．Angewandte Chemie-International Edition, 2014, 53, 4551-4555. （SCI-IF：12.959）
27. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.Angewandte Chemie-International Edition, 2013, 52, 4375-4379. （SCI-IF：12.959）
28. Huilin Zhang, Jinjin Li, Yang Chen, Jiyue Wu, Kun Wang, Lije Chen, Ya Wang, Xingwu Jiang, Yanyan Liu, Yelin Wu, Dayong Jin, Wenbo Bu* Magneto-electrically enhanced intracellular catalysis of FePt-FeC heterostructures for cancer chemodynamic therapy.Advanced Materials, 2021, 33 (17), 2100472.（SCI-IF：27.398）
29. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu*Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy.Advanced Materials, 2020, 32 (4), 1904011（SCI-IF：27.398）
30. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.Advanced Materials, 2017, 29, 1701683. （SCI-IF：27.398）
31. Wenpei Fan, Wenbo Bu*, Jianlin Shi On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles. Advanced Materials, 2016, 28, 3987–4011.（SCI-IF：27.398）
32. Wenpei Fan, Wenbo Bu*, Bo Shen, Qianjun He, Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.Advanced Materials, 2015, 27, 4155–4161. （SCI-IF：27.398）
33. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．Advanced Materials, 2014, 26, 3867–3872. （SCI-IF：27.398）
