课题组开发及运用新型生物医学技术，探讨疾病组织的病理生理特征、发生发展机制与干预策略。主持国家级青年人才项目、国家自然科学基金面上基金、上海市基础研究重大项目、科技部重点研发计划课题，参与国家自然科学基金重点项目等项目。概况为：
1. 器官芯片微生理系统与组织工程动物模型，应用于病因研究及药物筛选。2. 生命分析化学技术与器件，开展针对临床疾病相关小分子、蛋白质等分析。
现在承担和参与的课题：
1. 国家自然科学基金面上基金-医学科学部H02循环系统，周期性张应力下NOTCH1低表达加剧主动脉平滑肌细胞线粒体功能障碍的机制及干预研究，2021-2024，55万，主持
2. 国家自然科学基金面上基金-医学科学部H18影像医学与生物医学工程，基于微流控与质谱联用的heme催化过敏原蛋白硝基化反应的体外模拟研究，2018-2021，55万元，主持
3. 上海市科委重大基础研究项目，面向药物筛选的微流控仿生器官芯片技术研究，2018-2021，1200万元，主持
4. 科技部重点研发计划，2018YFC1005002，ART对胚胎表观遗传的影响及方案优化，2018-2021，303万，课题2负责人
5. 上海市市级科技重大专项“国际人类表型组计划”项目五“人类表型特征的跨尺度关联及精细调控原理”子项目，微环境力学刺激对血管平滑肌表型的影响及分子机制，2020-2021，60万，主持
6. 国家自然科学基金青年基金，微流控重组酶聚合酶扩增用于原肌球蛋白悬浮颗粒物的微量样品采样与分析方法，2018已结题，主持
7. 国家重大科研仪器研制项目，全光控蛋白标志物BNP/NT-proBNP即时检测设备研制，2020-2024，参与（材料系俞燕蕾教授主持）
8. 国家自然科学基金重点项目，光响应液晶高分子新材料及其生物微流控芯片构筑，2018/01-2022/12，参与（材料系俞燕蕾教授主持）
9. 中组部海外青年高层次人才计划\上海市高校特聘教授计划 \上海市浦江人才计划
申请专利情况
专利名称：一种基于3D打印的细胞均一性分布的生物墨水及其装配方法
专利发明人：朱铠、孙晓宁、陈楠、张炜佳、程蕾蕾、王春生
基于以下论文内容：Nan Chen, Kai Zhu*, Yu Shrike Zhang, Shiqiang Yan, Tianyi Pan, Mieradilijiang Abudupataer, Guodong Yu, Md Fazle Alam, Li Wang, Xiaoning Sun, Yanlei Yu, Chunsheng Wang*, Weijia Zhang*. Hydrogel Bioink with Multilayered Interfaces Improves Dispersibility of Encapsulated Cells in Extrusion Bioprinting, ACS applied materials & interfaces, 2019, 11, 30585-95.
1. Wenrui Ma, Jingjing Zhang, Shaowen Liu, Shiqiang Yan, Kehua Xu, Yu Shrike Zhang, Mieradilijiang Abudupataer, Yang Ming, Shichao Zhu, Bitao Xiang, Xiaonan Zhou, Shaman Luo, Hui Huang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Nan Chen, Xiaoning Sun, Jun Li, Hao Lai, Chunsheng Wang*, Kai Zhu*, Weijia Zhang*, Patient-Derived Microphysiological Model Identifies the Therapeutic Potential of Metformin for Thoracic Aortic Aneurysm. eBiomedicine, 2022, doi:10.1016/j.ebiom.2022.104080.
2. Hui Huang, Youpei Lin, Wenrui Ma, Jiannan Liu, Jing Han, Xiaoyi Hu, Meilin Tang, Shiqiang Yan, Chenping Zhang, Qiang Gao, Weijia Zhang*, A Pre-Screening Strategy to Assess Resected Tumor Margins by Imaging Mitochondrial Viscosity and Hypoxia. eLife, 2021, 10, 70471.
3. Mieradilijiang, A., Zhu, S., Yan, S., Xu, K., Zhang, J., Luo, S., Ma, W., Alam, M. F., Tang, Y., Huang, H., Chen, N., Wang, L., Yan, G., Li, J., Lai, H., Wang, C.*, Zhu, K.*, and Zhang, W.* Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease. eLife, 2021, 10, 69310.
4. Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Weijia Zhang*, Yao Lu*. Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13, 035001.
5. Nan Chen, Kai Zhu*, Yu Shrike Zhang, Shiqiang Yan, Tianyi Pan, Mieradilijiang Abudupataer, Guodong Yu, Md Fazle Alam, Li Wang, Xiaoning Sun, Yanlei Yu, Chunsheng Wang*, Weijia Zhang*. Hydrogel Bioink with Multilayered Interfaces Improves Dispersibility of Encapsulated Cells in Extrusion Bioprinting ACS applied materials & interfaces 2019, 11, 30585.
6. Yangyang Zhou#, Weina Fang#, Keqiang Lai, Yongheng Zhu, Xiaojun Bian, Jianlei Shen, Qian Li, Lihua Wang, Weijia Zhang*, Juan Yan*, Terminal deoxynucleotidyl transferase (TdT)-catalyzed homo-nucleotides- constituted ssDNA: Inducing tunable-size nanogap for core-shell plasmonic metal nanostructure and acting as Raman reporters for detection of Escherichia coli O157: H7. Biosensors and Bioelectronics 2019, 141, 111419.
7. Zhang, Q.; Huang, Y.; Jiang, B.; Hu, Y.; Xie, J.; Gao, X.; Jia, B.; Shen, H.; Zhang, W.*; Yang, P.* In situ Synthesis of Magnetic Mesoporous PhenolicResin for the Selective Enrichment of Glycopeptides. Analytical Chemistry, 2018, 90, 7357.
8. Zhang Y.S.*, Zhang Y., and Zhang, W.* Cancer-on-a-chip systems at the frontier of nanomedicine. Drug discovery today 2017, 22, 1392-1399.
9. Zhang, W.#, Zhang, Y.S.#, Bakht, S.M.#, Aleman, J., Shin, S.R., Yue, K., Sica, M., Ribas, J., Duchamp, M., Ju, J., Sadeghian, R.B, Kim.,D, Dokmeci, M.R., Atala, A., Khademhosseini, A.*,Elastomeric Free-Form Blood Vessels for Interconnecting Organs on Chip Systems, Lab on a Chip 2016, 16, 1579-1586. (Cover, Lab on Chip Hot Articles)
10.Zhang, W., Kai, K., Choi, D.S., Iwamoto, T., Nguyen, Y.H., Wong, H., Landis, M.D., Ueno, N.T.*, Chang, J.*, and Qin, L.* Microfluidics Separation Reveals the Stem-Cell–Like Deformability of Tumor-Initiating Cells, Proceedings of the National Academy of Sciences 2012, 109, 18707-18712. (Highlighted by Nature Methods 2013, 10, 14; Lab on Chip, 2013, 13, 599.)
11. Zhang, W., Liu, Y., Cao, R., Li, Z., Zhang, Y., Tang, Y.,* Fan, K. Journal of the American Chemical Society 2008, 130, 15581-15588.
