生物医用发光材料
现在承担和参与的课题：
1. 国家自然科学基金重点项目，活体水平的时间分辨生物成像与检测技术，21937003，2020.1-2024.12，总经费300万，项目负责人，承担经费300万元。正在进行中。
2. 科技部国家重点研发计划纳米科技重点专项，基于稀土发光纳米技术的病原体检测研究，2017YFA0205100，2017.7-2022.6，总经费2678万，项目负责人，承担经费625.17万元。正在进行中。
3. 国家自然科学基金面上项目，21874027，2019.1-2022.12，总经费66万，项目负责人，承担经费66万元。正在进行中。
4. 国家自然科学基金重大科研仪器研制项目，上转换发光成像指导定位和测温的光热治疗系统研制，21527801，2016.1-2020.12，总经费688.236万，项目负责人，承担经费628.236万元。已结题。
5. 科技部，国家重大科学研究计划子课题，肺癌在体分子分型的新型纳米分子成像探针基础研究，2015CB931801，2015.1-2019.8，总经费590万元，课题参与人，承担经费190万元。已结题。
6. 度痕迹科学与技术公安部重点实验室开放课题，适配体功能化的上转换纳米探针智能化手印成像技术，2015FMKFKT01，2015.10-2017.9，总经费10万元，课题负责人，承担经费10万元。已结题。
7. 国家自然科学基金面上项目，基于能量转移的纳米探针用于活体上转换发光成像检测，21375024，2014.01-2017.12，总经费80万，项目负责人，承担经费80万元。已结题。
8. 国家自然科学基金重点项目，面向生物医学成像应用的上转换发光标记的基础研究，21231004，2013.1-2017.12，总经费280万，项目负责人，承担经费190万元。已结题。
9. 科技部，国家重点研究基础发展计划项目子课题，硅纳米结构的荧光标记应用的基础研究，2012CB932403，2012.7-2017.6，总经费676万，课题负责人，承担经费351万元。已结题
申请专利情况
1. 发明人：李富友，徐明，冯玮；发明专利：基于三线态-三线态湮灭上转换发光的温度检测材料，申请号：201810141456.8,申请日：2018.2.11。授权号：ZL201810141456.8；授权公告日：2021.1.5。
2. 发明人：李富友，刘青昀，冯玮，吴勇；发明专利：一种含聚苯乙烯壳层的稀土纳米材料及其生物偶联与应用，申请号：201910894983.0,申请日：2019.9.20。授权号：ZL 201910894983.0；授权公告日：2020.12.1。
3. 发明人：李富友，冯玮，朱幸俊；发明专利：一种上转换发光-热化疗符合纳米探针及其制备方法和联合治疗程序化控制的应用，申请号：201810037868.7,申请日：2018.1.16。授权号：ZL201810037868.7；授权公告日：2020.6.12。
4. 发明人：李富友，朱幸俊，李家畅；发明专利：一种光致发光-光热纳米复合结构材料及其制备方法和应用，申请号：201610008323.4，申请日：2016.1.7。授权号：ZL201610008323.4；授权公告日：2019.11.12。
5. 发明人：李富友，冯玮，朱幸俊；实用新型专利：激光泵浦时间分辨上转换发光活体成像系统，申请号：201620063328.2，申请日：2016.1.22。授权号：ZL201620063328.2；授权公告日：2016.8.17。
6. 发明人：李富友，朱幸俊，李家畅；实用新型专利：激光泵浦上转换荧光测温系统，申请号：201620008102.2，申请日：2016.1.7。授权号：ZL201620008102.2；授权公告日：2016.8.10。
7. 发明人：李富友，朱幸俊，李家畅；发明专利：激光泵浦上转换荧光测温系统，申请号：201610005174.6，申请日：2016.1.7。授权号：ZL201610005174.6；授权公告日：2019.11.12。
8. 发明人：李富友，刘倩；发明专利名称：一种超分子自组装制备水溶性稀土纳米粒子的方法, 申请号：201010191594.0, 申请日 2010.06.03；授权号：ZL201010191594.0；授权状态公告日：2012.05.23
1. 李富友，2016年国家高层次人才特殊支持计划领军人才。
2. 李富友，2019年上海市庄长恭化学化工科学技术进步奖。
3. 李富友（第二完成人），“光响应高分子材料”，2019年上海市自然科学一等奖。
1. Yawei Liu, Yuyang Gu, Wei Yuan, Xiaobo Zhou, Xiaochen Qiu, Mengya Kong, Qingbing Wang, Wei Feng, Fuyou Li*, Quantitative Mapping of Liver Hypoxia in Living Mice Using Time-Resolved Wide-Field Phosphorescence Lifetime Imaging, Adv. Sci., 2020, 7, 1902929.
2. Xiaochen Qiu, Qianwen Zhou, Xingjun Zhu, Zugen Wu, Wei Feng*, Fuyou Li*, Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique, Nat. Commun., 2020, 11, 4.
3. Yuyang Gu, Zhiyong Guo, Wei Yuan, Mengya Kong, Yulai Liu, Yongtao Liu, Yilin Gao, Wei Feng*, Fan Wang, Jiajia Zhou, Dayong Jin*, Fuyou Li*, High-sensitivity imaging of time-domain near-infrared light transducer, Nat. Photon., 2019, 13, 525.
4. Xiaochen Qiu, Xingjun Zhu, Xianlong Su, Ming Xu, Wei Yuan, Qingyun Liu, Meng Xue, Yawei Liu, Wei Feng*, Fuyou Li*, Near-Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots, Adv. Sci. 2019, 1801834.
5. Shengming Cheng, Bin Shen, Wei Yuan, Xiaobo Zhou, Qingyun Liu, Mengya Kong, Yibing Shi, Pengyuan Yang, Wei Feng*, and Fuyou Li*, Time-Gated Ratiometric Detection with the Same Working Wavelength to Minimize the Interferences from Photon Attenuation for Accurate in Vivo Detection, ACS Central Sci., 2019, 5, 299.
6. Mengya Kong, Yuyang Gu, Yulai Liu, Yibing Shi, Na Wu, Wei Feng*, Fuyou Li*, Luminescence Lifetime-Based In Vivo Detection with Responsive Rare Earth-Dye Nanocomposite, Small, 2019, 1904487.
7. Ming Xu, Xianmei Zou, Qianqian Su, Wei Yuan, Cong Cao, Qiuhong Wang, Xingjun Zhu, Wei Feng*, Fuyou Li*, Ratiometric Nanothermometer in Vivo Based on Triplet-Sensitized Upconversion, Nat. Commun., 2018, 9,2698.
8. Xingjun Zhu, Jiachang Li, Xiaochen Qiu, Yi Liu, Wei Feng*, Fuyou Li*, Upconversion Nanocomposite for Programming Combination Cancer Therapy by Precise Control of Microscopic Temperature, Nat. Commun., 2018, 9, 2176
9. Xingjun Zhu§, Wei Feng§, Jian Chang, Yan-Wen Tan, Jiachang Li, Min Chen, Yun Sun & Fuyou Li*, Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature, Nat. Commun., 2016, 7, 10437. DOI: 10.1038/ncomms10437.
10. Qian Liu, Wei Feng, Tianshe Yang, Tao Yi, Fuyou Li*, Upconversion Luminescence imaging of cells and small-animals, Nat. Protoc., 2013, 8(10), 2033-2044.
11. Jing Zhou, Qian Liu, Wei Feng, Yun Sun, Fuyou Li*, Upconversion Luminescence Materials: Advances and Application, Chem. Rev., 2015, 115, 395−465.
12. Yuming Yang, Qiang Zhao, Wei Feng, Fuyou Li*, Luminescent Chemodosimeters for Bioimaging, Chem. Rev., 2013, 113, 192-270.
13. Xingjun Zhu, Qianqian Su, Wei Feng*, Fuyou Li*, Anti-Stokes shift luminescent materials for bio-applications, Chem. Soc. Rev., 2017, 46, 1025-1039.
14. Yun Sun, Wei Feng, Pengyuan Yang, Chunhui Huang, and Fuyou Li,* The biosafety of lanthanide upconversion nanomaterials, Chem. Soc. Rev., 2015, 44(6), 1509-1525.
15. Jing Zhou, Zhuang Liu, Fuyou Li*, Upconversion Nanophosphors for Small-animal Imaging, Chem. Soc. Rev., 2012, 41, 1323–1349.
16. Qiang Zhao, Chunhui Huang, Fuyou Li*, Phosphorescent Heavy-metal Complexes for Bioimaging, Chem. Soc. Rev., 2011, 40 (5), 2508 - 2524.
17. Qiang Zhao, Fuyou Li,* Chunhui Huang, Phosphorescent Chemosensors Based on Heavy-metal Complexes, Chem. Soc. Rev., 2010, 39, 3007 – 3030.
18. Qianqian Su, Wei Feng, Dongpeng Yang, Fuyou Li*, Resonance Energy Transfer in Upconversion Nanoplatforms for Selective Biodetection, Acc. Chem. Res., 2017, 50, 32–40.
19. Yi Liu, Qianqian Su, Min Chen, Yi Dong, Yibing Shi, Wei Feng, Zhi-Ying Wu, Fuyou Li*, Near-Infrared Upconversion Chemodosimeter for in Vivo Detection of Cu2+ in Wilson Disease, Adv. Mater., 2016. 28, 6625–6630.
20. Wei Feng, Chunmiao Han, Fuyou Li*, Upconversion-Nanophosphor-Based Functional Nanocomposites, Adv. Mater., 2013, 25(37), 5287–5303.
21. Jihye Park, Ming Xu, Fuyou Li*, Hong-Cai Zhou*, 3D Long-Range Triplet Migration in a Water-Stable Metal–Organic Framework for Upconversion-Based Ultralow-Power in Vivo Imaging, J. Am. Chem. Soc., 2018, 140, 5493-5499.
22. Yuhao Li, YunSun, Jiachang Li, Qianqian Su, Wei Yuan, Yu Dai, Chunmiao Han, Qiuhong Wang, Wei Feng*, Fuyou Li *, Ultrasensitive Near-Infrared Fluorescence-Enhanced Probe for In Vivo Nitroreductase Imaging, J. Am. Chem. Soc., 2015, 137 (19), 6407–6416. ASAP DOI: 10.1021/jacs.5b04097.
23. Zhen Jiang,| Ming Xu,| Fuyou Li*, Yanlei Yu*, Red-light Controllable Liquid-Crystal Soft Actuators via Low-power Excited Upconversion Based on Triplet-Triplet Annihilation, J. Am. Chem. Soc., 2013, 135, 16446-16453.
24. Yi Liu, Min Chen, Tianye Cao, Yun Sun, Chunyan Li, Qian Liu, Tianshe Yang, Liming Yao, Wei Feng, Fuyou Li*, A Cyanine-modified Nanosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury, J. Am. Chem. Soc., 2013, 135, 9869-9876. （被同行认为是“针对小鼠肝、脾进行活体检测的第一个例子）
25. Qian Liu, Baoru Yin, Tianshe Yang, Yongchao Yang, Zhen Shen, Ping Yao, Fuyou Li*, A general strategy for biocompatible, high-effective upconversion nanocapsules based on triplet-triplet annihilation, J. Am. Chem. Soc., 2013, 135, 5029–5037.
26. Qian Liu, Tianshe Yang, Wei Feng, Fuyou Li*, Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo, J. Am. Chem. Soc., 2012, 134 (11), 5390–5397.（被同行认为是“TTA上转换发光活体成像的第一个例子”）
27. Chunyan Li, Mengxiao Yu, Yun Sun, Yongquan Wu, Chunhui Huang, Fuyou Li*, A Nonemissive Iridium(III) Complex That Specifically Lights-up the Nuclei of Living Cells, J. Am. Chem. Soc., 2011, 133, 11231–11239. （Highlighted by C&EN）
28. Jinliang Liu, Yi Liu, Qian Liu, Chunyan, Li, Lining Sun, Fuyou Li*, Iridium(III) Complex-coating Lanthanide Nanosystem for Upconversion Luminescence Detection and Bio-imaging of Cyanide Anions, J. Am. Chem. Soc., 2011, 133, 15276–15279.
29. Wei Wu, Liming Yao, Tianshe Yang, Ruoyuan Yin, Fuyou Li*, Yanlei Yu*, NIR-Light-Induced Deformation of Cross-Linked Liquid-Crystal Polymers Using Upconversion Nanophosphors, J. Am. Chem. Soc., 2011, 133, 15810–15813.
30. Qian Liu, Yun Sun, Tianshe Yang, Wei Feng, Chenguang Li, Fuyou Li*, Sub-10 nm hexagonal lanthanide-doped NaLuF4 upconversion nanocyrstals for super-sensitive bioimaging in vivo, J. Am. Chem. Soc., 2011, 133, 17122–17125.
31. Zhigang Chen, Huili Chen, He Hu, Mengxiao Yu, Fuyou Li,* Qiang Zhang, Zhiguo Zhou, Tao Yi, Chunhui Huang*, Versatile Synthesis Strategy for Carboxylic Acid-functionalized Upconverting Nanophosphors as Biological Labels, J. Am. Chem. Soc., 2008, 130, 3023-3029. （被同行认为“第一次报道了配体氧化的方法用于上转换发 光纳米材料的水溶性改性）
32. Meng Zhang, Mengxiao Yu, Fuyou Li,* Minwei Zhu, Menyu Li, Yanhong Gao, Lei Li, Zhiqiang Liu, Jianping Zhang, Dengqing Zhang, Tao Yi, Chunhui Huang*, A Highly Selective Fluorescence Turn-on Sensor for Cysteine/Homocysteine and Its Application in Bioimaging, J. Am. Chem. Soc., 2007, 129, 10322-10323.
33. Yun Sun, Xingjun Zhu, Juanjuan Peng, Fuyou Li*, Core-shell lanthanide upconversion nanophorsphors as four-modal probes for tumor angiogenesis imaging, ACS Nano, 2013, 7 (12), 11290–11300.
34. Qian Liu, Yun Sun, Chenguang Li, Jing Zhou, Chunyan Li, Tianshe Yang, Xianzhong Zhang, Tao Yi*, Dongmei Wu, and Fuyou Li*, 18F-labeled Magnetic-upconversion Nanophosphors via Rare-earth Cation-assisted Ligand Assembly, ACS Nano, 2011, 5(4), 3146-3157.
35. Qian Liu, Juanjuan Peng, Chunyan Li, Lining Sun, Fuyou Li*, High-efficiency Upconversion Luminescent Sensing and Bioimaging of Hg(II) by Chromophoric Ruthenium Complex-Assembled Nanophosphors, ACS Nano, 2011, 5(10), 8040-8048.
36. Wei Yuan, Dongpeng Yang, QianQian Su, Xingjun Zhu, Tianye Cao, Yun Sun, Yu Dai, Wei Feng, Fuyou Li*, Intraperitoneal Administration of Biointerface-Camouflaged Upconversion Nanoparticles for Contrast Enhanced Imaging of Pancreatic Cancer, Adv. Funct. Mater., 2016, 26(47), 8631-8642.
37. Yuxin Liu, Quanwei Guo, Xingjun Zhu, Wei Feng, Senzhi Li, Luoyuan Li, Lu Wang, Jing Zhou*, Fuyou Li*. Optimization of Prussian Blue Coated NaDyF4:x%Lu Nanocomposites for Multifunctional Imaging-Guided Photothermal Therapy. Adv. Funct. Mater., 2016, 26, 28, 5120–5130.
38. Huiran Yang , Chunmiao Han , Xingjun Zhu , Yi Liu , Kenneth Yin Zhang , Shujuan Liu, Qiang Zhao*, Fuyou Li*, Wei Huang*, Upconversion Luminescent Chemodosimeter Based on NIR Organic Dye for Monitoring Methylmercury In Vivo, Adv. Funct. Mater. 2016, 26, 1945–1953.
39. Lingzhi Zhao, Wei Yuan, Chung Yen Ang, Qiuyu Qu, Yu Dai, Yilin Gao, Zhong Luo, Jingui Wang, Hongzhong Chen, Menghuan Li, Fuyou Li,* and Yanli Zhao*, Silica–Polymer Hybrid with Self-Assembled PEG Corona Excreted Rapidly via a Hepatobiliary Route, Adv. Funct. Mater. 2016, 26, 3036–3047.
40. Lingzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Wei Feng, Linyong Zhu,* Fuyou Li*, Near-infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk-shell Up-conversion Nanocages, Adv. Funct. Mater., 2014, 24, 363–371.
41. Liming Yao, Jing Zhou, Jinliang Liu, Wei Feng*, Fuyou Li*, Iridium Complex-Modified Upconversion Nanophosphors for Effective LRET Detection of Cyanide Anions in Pure Water, Adv. Funct. Mater., 2012, 22 (13), 2667-2672.
42. Wei Feng, Xingjun Zhu, and Fuyou Li*, Recent advances in the optimization and functionalization of upconversion nanomaterials for in vivo bioapplications, NPG Asia Mater., 2013, 5, e75.
43. Zhenhua Li, Hang Yuan, Wei Yuan, Qianqian Su, Fuyou Li*, Upconversion nanoprobes for biodetections, Coord. Chem. Rev., 2018, 354,155-168.
44. Qian Liu, Wei Feng, Fuyou Li*, Water-soluble lanthanides upconversion nanophosphors: Synthesis and bioimaging application in vivo, Coord. Chem. Rev., 2014, 273/274, 100–110.
45. Mengxiao Yu, Fuyou Li,* Zhigang Chen, He Hu, Cheng Zhan, Hong Yang, Chunhui Huang, Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors, Anal. Chem., 2009, 81(3), 930–935. （该工作被同行认为，“发展了一种新的具有极少光漂 白和背景荧光干扰的三维可视化成像技术” 、“第一次实现了上转换发光激光扫描共聚焦成像”、 “第一次定量描述 了利用上转换发光纳米粒子进行成像时获得的高对比度”）
