开展医学大数据、影像人工智能和知识图谱方向的研究

现在承担和参与的课题：

［1］上海市“地高建”项目，复旦大学上海医学院医学科研数据中心，项目编号：DGF501010；年度：2020-持续，项目负责人， 经费：2879万

［2］国家重点研发计划“精准医学研究”重点专项“疾病研究精准医学知识库构建”项目，项目编号：2016YFC09011900；年度：2016-2020，项目首席，经费：4632万。

申请的发明专利：

［1］刘雷; 周凌霄; 施李丽, 一种医学影像知识库的构建方法及应用, 2018.11.30,中国, 201811457753.X    (专利)       实审

［2］刘雷; 周凌霄; 任和, 一种基于CT影像的肺结节分割方法, 2018.10.09, 中国, 201811180885    (专利)        实审

［3］刘雷; 周凌霄; 朱超宇, 一种混合专家系统在肺腺癌分类中给的应用方法,2019.08.23, 中国, 201910782827.5    (专利)       实审

［4］刘雷; 周凌霄; 王云鹏, 基于GAN和CNN的CT图像数据自动分类方法及设备2019.11.25, 中国, 201911163273.7    (专利)   提交申请

［1］Cui, D., Liu, Y., Liu, G., and Liu, L. (2020). A Multiple-Instance Learning-Based Convolutional Neural Network Model to Detect the IDH1 Mutation in the Histopathology Images of Glioma Tissues. Journal of computational biology : a journal of computational molecular cell biology.

［2］Liu, Y., Dou, Y., Lu, F., and Liu, L. (2020). A study of radiomics parameters from dual-energy computed tomography images for lymph node metastasis evaluation in colorectal mucinous adenocarcinoma. Medicine 99, e19251.

［3］Ren, H., Zhou, L., Liu, G., Peng, X., Shi, W., Xu, H., Shan, F., and Liu, L. (2020). An unsupervised semi-automated pulmonary nodule segmentation method based on enhanced region growing. Quantitative Imaging in Medicine and Surgery 10, 233-+.

［4］Xu, W.F., Liu, Z.H., Ren, H., Peng, X.Q., Wu, A.S., Ma, D., Liu, G., and Liu, L. (2020). Twenty Metabolic Genes Based Signature Predicts Survival of Glioma Patients. J Cancer 11, 441-449.

［5］Chen, L., Liu, X., Li, M., Wang, S., and Cheng, X. (2019). A novel model to predict cancer﹕pecific survival in patients with early﹕tage uterine papillary serous carcinoma (UPSC). Cancer Medicine 9.

［6］Li, Y., Wu, A., Liu, G., and Liu, L. (2019). A Review of Methods to Quantify the Genomic Similarity of Topological Associating Domains. Journal of Computational Biology A Journal of Computational Molecular Cell Biology.

［7］Liu, X.-N., Cui, D.-N., Li, Y.-F., Liu, Y.-H., Liu, G., and Liu, L. (2019a). Multiple Omics data-based biomarker screening for hepatocellular carcinoma diagnosis. World Journal of Gastroenterology.

［8］Liu, Y., Yang, N., Peng, X., Liu, G., Zhong, H., and Liu, L. (2019b). One-lincRNA and five-mRNA based signature for prognosis of multiple myeloma patients undergoing proteasome inhibitors therapy. Biomedicine & Pharmacotherapy 118, 109254.

［9］Shi, W., Zhou, L., Peng, X., Ren, H., and Shi, Y. (2019). HIV-infected patients with opportunistic pulmonary infections misdiagnosed as lung cancers: the clinicoradiologic features and initial application of CT radiomics. Journal of Thoracic Disease 11, 2274-2286.

［10］Zhan, Y., Peng, X., Shan, F., Feng, M., and Zhang, Z. (2019). Attenuation and Morphologic Characteristics Distinguishing a Ground-Glass Nodule Measuring 5–10 mm in Diameter as Invasive Lung Adenocarcinoma on Thin-Slice CT. American Journal of Roentgenology 213, 1-9.

［11］Dong, C., Cui, D., Liu, G., Xu, H., Peng, X., Duan, J., and Liu, L. (2018). Cancer stem cell associated eight gene‑based signature predicts clinical outcomes of colorectal cancer. Oncology Letters.

［12］Liu, G., Chen, L., Ren, H., Liu, F., Dong, C., Wu, A., Liu, Z., Zheng, Y., Cheng, X., and Liu, L. (2018a). Seven Genes Based Novel Signature Predicts Clinical Outcome and Platinum Sensitivity of High Grade IIIc Serous Ovarian Carcinoma. International Journal of Biological Sciences 14, 2012-2022.

［13］Liu, Z.H., Lian, B.F., Dong, Q.Z., Sun, H., Wei, J.W., Sheng, Y.Y., Li, W., Li, Y.X., Xie, L., and Liu, L. (2018b). Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity. Biochimica Et Biophysica Acta, S0925443918300383.

［14］Dong, C., Wang, X., Xu, H., Zhan, X., Ren, H., Liu, Z., Liu, G., and Liu, L. (2017). Identification of a cytokine-cytokine receptor interaction gene signature for predicting clinical outcomes in patients with colorectal cancer. International Journal of Clinical & Experimental Medicine 10, 9009-9018.

［15］ Hou, G., Chen, L., Liu, G., Li, L., Yang, Y., Yan, H.X., Zhang, H.L., Tang, J., Yang, Y.C., Lin, X., et al. (2017a). Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice. Hepatology 65, 1628-1644.

［16］Hou, G., Dong, C., Dong, Z., Liu, G., Xu, H., Chen, L., Liu, L., Wang, H., and Zhou, W. (2017b). Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types. Scientific Reports 7, 4148.

［17］Huang, T.B., Dong, C.P., Zhou, G.C., Lu, S.M., Luan, Y., Gu, X., Liu, L., and Ding, X.F. (2017). A potential panel of four-long noncoding RNA signature in prostate cancer predicts biochemical recurrence-free survival and disease-free survival. International Urology & Nephrology 49, 825-835.

［18］Liu, G., Dong, C., Wang, X., Hou, G., and Zheng, Y. (2017a). Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma. Oncotarget 8, 98360.

［19］Liu, G., Zhan, X., Dong, C., and Liu, L. (2017b). Genomics alterations of metastatic and primary tissues across 15 cancer types. Scientific Reports 7, 13262.

［20］Qiao, N., Ren, H., and Liu, L. (2017). Genomic diversity and phylogeography of norovirus in China. Bmc Medical Genomics 10, 51.

［21］Zhan, X., Dong, C., Gang, L., Li, Y., and Lei, L. (2017). Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer. Oncotargets & Therapy Volume 10, 2805-2813.

［22］刘雷*. 中国精准医学的发展[J]. 科学, 2016, 68(6):22-26.

［23］Gang Liu, Chuanpeng Dong, Lei Liu*. Integrated Multiple “-omics” Data Reveal Subtypes of Hepatocellular Carcinoma Plos One, 2016; 11(11): e0165457.

［24］Yin Wang, Tao Huang, Lu Xie  and Lei Liu Integrative analysis of methylation and transcriptional profiles to predict aging and construct aging specific cross-tissue networks, BMC systems biology ,201610(4):413-421.

［25］Yuan Sheng-Xian，Wang Jie，Yang Fu，Tao Qi-Fei，Zhang Jin，Wang Li-Li，Yang Yuan，Liu Hui，Wang Zhen-Guang，Xu Qing-Guo，Fan Jia，Liu Lei*，Sun Shu-Han，Zhou Wei-Ping，Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1.，Hepatology，2016，63（2）：499-511.

［26］Gang Liu, GuojunHou, Liang Li, Yixue Li, Weiping Zhou*, Lei Liu*, Potential diagnostic and prognostic marker dimethylglycine dehydrogenase  (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo, Oncotarget, 2016, 7(22): 32607-32616.

［27］GuojunHou*, Gang Liu*, Yuan Yang*, Yixue Li, Shengxian Yuan, LinghaoZhao, Mengchao Wu, Lei Liu, Weiping Zhou，Neuraminidase 1 (NEU1) promotes proliferation and migration as a diagnostic and prognostic biomarker of hepatocellular carcinoma，Oncotarget, 2016,7(40):64957-64966.

［28］JinGan, NiuQiao, Roxanne Strahan, Caixia Zhu, Lei Liu, Subhash C. Verma, Fang Wei, QiliangCai, Manipulation of ubiquitin/SUMO pathways in human herpesviruses infection, Reviews in Medical Virology, 2016, DOI: 10.1002/rmv.1900,1099-1654

［29］NiuQiao, Xuan-Yi Wang, Lei Liu*, Temporal Evolutionary Dynamics of Norovirus GII.4 Variants in China between 2004 and 2015, PLoS ONE，2016,11(9):e0163166. doi: 10.1371/journal.pone.0163166.

［30］Liang Yan, Su Qu, Gang Liu, Lei Liu, Yao Yu, GuohuiDing,Yanfeng Zhao, Yixue Li, YouhuaXie*, Junqi Zhang*, Di Qu*，Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection，PLoS ONE，2016，11(2),DOI:10.1371/journal.pone.0149702 .

［31］ Yin Wang, Rudong Li, Yuhua Zhou, Zongxin Ling, XiaokuiGuo, Lu Xie, Lei Liu* ,Motif-based text mining of microbial metagenome redundancy profiling data for disease classification, BioMed Research International, Volume 2016 (2016), Article ID 6598307, 11 pages http://dx.doi.org/10.1155/2016/6598307.

［32］ Yin Wang, Rudong Li, Yuhua Zhou, Lei Liu, et al., Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification,BioMed Research International, vol. 2016, Article ID 6598307, 11 pages, 2016. doi:10.1155/2016/6598307.

［33］ Qin Meilin，Liu Gang，HuoXisong，Tao Xuemei，Sun Xiaomeng，Ge Zhouhong，Yang Juan，Fan Jia，Liu Lei*，Qin Wenxin，Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma.，Cancer Biomarkers，2016，16（1）：161-169.